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1. (WO2017038925) PHARMACEUTICAL COMPOSITION CONTAINING RAPAMYCIN OR DERIVATIVE THEREOF

Pub. No.:    WO/2017/038925    International Application No.:    PCT/JP2016/075617
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: A61K 31/436
A61K 47/22
A61K 47/26
A61K 47/38
A61P 1/04
A61P 1/16
A61P 3/10
A61P 11/00
A61P 13/12
A61P 17/00
A61P 17/06
A61P 19/02
A61P 21/04
A61P 25/00
A61P 27/02
A61P 29/00
A61P 37/06
Applicants: NIPPON KAYAKU KABUSHIKI KAISHA
日本化薬株式会社
Inventors: KAWAMURA Dai
川村 大
Title: PHARMACEUTICAL COMPOSITION CONTAINING RAPAMYCIN OR DERIVATIVE THEREOF
Abstract:
The present invention addresses the problem of providing a pharmaceutical composition that has a high safety and with which the long-term stability can be ensured and the reduction in the amount of an active ingredient accompanying the oxidation or decomposition of rapamycin or a derivative thereof is inhibited. The invention of this pharmaceutical preparation containing rapamycin or a derivative thereof was achieved after discovering that the oxidation or decomposition of rapamycin or a derivative thereof can be inhibited by using: a salt of a chelating agent; and/or (B) ascorbic acid or a salt of a derivative of (B) ascorbic acid. Preferably, the rapamycin or the derivative thereof, and the salt of a chelating agent and/or (B) ascorbic acid or a salt of a derivative of (B) ascorbic acid are a solid mixture prepared by preparing a solution that contains said components and then removing the solvent from the solution.