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|1. (WO2017038925) PHARMACEUTICAL COMPOSITION CONTAINING RAPAMYCIN OR DERIVATIVE THEREOF|
|Applicants:||NIPPON KAYAKU KABUSHIKI KAISHA
|Title:||PHARMACEUTICAL COMPOSITION CONTAINING RAPAMYCIN OR DERIVATIVE THEREOF|
The present invention addresses the problem of providing a pharmaceutical composition that has a high safety and with which the long-term stability can be ensured and the reduction in the amount of an active ingredient accompanying the oxidation or decomposition of rapamycin or a derivative thereof is inhibited. The invention of this pharmaceutical preparation containing rapamycin or a derivative thereof was achieved after discovering that the oxidation or decomposition of rapamycin or a derivative thereof can be inhibited by using: a salt of a chelating agent; and/or (B) ascorbic acid or a salt of a derivative of (B) ascorbic acid. Preferably, the rapamycin or the derivative thereof, and the salt of a chelating agent and/or (B) ascorbic acid or a salt of a derivative of (B) ascorbic acid are a solid mixture prepared by preparing a solution that contains said components and then removing the solvent from the solution.