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1. (WO2017038815) CRYSTALS OF 5-CYCLOPROPYL-2-((1-(3-FLUOROBENZYL)-1H-INDOL-5-YL)AMINO)NICOTINIC ACID

Pub. No.:    WO/2017/038815    International Application No.:    PCT/JP2016/075318
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Wed Aug 31 01:59:59 CEST 2016
IPC: C07D 401/12
A61K 31/4439
A61P 17/00
A61P 17/06
A61P 35/00
Applicants: TOYAMA CHEMICAL CO., LTD.
富山化学工業株式会社
FUJIFILM CORPORATION
富士フイルム株式会社
Inventors: OKUBO Yusuke
大久保 裕介
TANAKA Tadashi
田中 正
Title: CRYSTALS OF 5-CYCLOPROPYL-2-((1-(3-FLUOROBENZYL)-1H-INDOL-5-YL)AMINO)NICOTINIC ACID
Abstract:
Crystals of 5-cyclopropyl-2-((1-(3-fluorobenzyl)-1H-indol-5-yl)amino)nicotinic acid having diffraction peaks at diffraction angles (2θ) of 12.2±0.2、17.2±0.2、19.4±0.2、24.1±0.2, and 27.1±0.2° or diffraction angles (2θ) of 12.9±0.2、15.5±0.2、21.2±0.2、21.7±0.2, and 25.9±0.2° in powder x-ray diffraction have excellent stability, are easy to handle, and are useful as a drug substance of pharmaceuticals to be used in treatments such as the prevention or treatment of diseases involving keratinocyte hyperproliferation.