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1. (WO2017038784) ROR1-POSITIVE MESENCHYMAL STEM CELLS AND METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION CONTAINING ROR1-POSITIVE MESENCHYMAL STEM CELLS AND METHOD FOR PREPARING SAME, AND METHOD FOR PREVENTING OR TREATING DISEASES BY USING ROR1-POSITIVE MESENCHYMAL STEM CELLS
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Pub. No.: WO/2017/038784 International Application No.: PCT/JP2016/075251
Publication Date: 09.03.2017 International Filing Date: 29.08.2016
IPC:
C12N 5/0775 (2010.01) ,A61K 35/28 (2015.01) ,A61P 1/00 (2006.01) ,A61P 1/16 (2006.01) ,A61P 1/18 (2006.01) ,A61P 3/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 19/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775
Mesenchymal stem cells; Adipose-tissue derived stem cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
18
for pancreatic disorders, e.g. pancreatic enzymes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
ロート製薬株式会社 ROHTO PHARMACEUTICAL CO., LTD. [JP/JP]; 大阪府大阪市生野区巽西1丁目8番1号 1-8-1, Tatsumi-nishi, Ikuno-ku, Osaka-shi, Osaka 5448666, JP
Inventors:
池山 芳史 IKEYAMA, Yoshifumi; JP
西田 浩之 NISHIDA, Hiroyuki; JP
津田 智博 TSUDA, Tomohiro; JP
宇野 栄子 UNO, Eiko; JP
湯本 真代 YUMOTO, Masayo; JP
須田 一真 SUDA, Kazuma; JP
吉野 みほ子 YOSHINO, Mihoko; JP
ノ スアン チュン NGO, Xuan Trung; JP
Agent:
特許業務法人 津国 TSUKUNI & ASSOCIATES; 東京都千代田区麹町5-3-1 麹町ビジネスセンター Kojimachi Business Center, 5-3-1, Kojimachi, Chiyoda-ku, Tokyo 1020083, JP
山村 大介 YAMAMURA, Daisuke; JP
森田 慶子 MORITA, Yoshiko; JP
Priority Data:
62/211,39028.08.2015US
62/268,14616.12.2015US
Title (EN) ROR1-POSITIVE MESENCHYMAL STEM CELLS AND METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION CONTAINING ROR1-POSITIVE MESENCHYMAL STEM CELLS AND METHOD FOR PREPARING SAME, AND METHOD FOR PREVENTING OR TREATING DISEASES BY USING ROR1-POSITIVE MESENCHYMAL STEM CELLS
(FR) CELLULES SOUCHES MÉSENCHYMATEUSES POSITIVES À ROR1 ET LEUR PROCÉDÉ DE PRÉPARATION, COMPOSITION PHARMACEUTIQUE LES CONTENANT ET SON PROCÉDÉ DE PRÉPARATION, ET MÉTHODE DESTINÉE À PRÉVENIR OU À TRAITER DES MALADIES À L'AIDE DESDITES CELLULES SOUCHES MÉSENCHYMATEUSES POSITIVES À ROR1
(JA) ROR1陽性の間葉系幹細胞及びその調製方法、ROR1陽性の間葉系幹細胞を含む医薬組成物及びその調製方法、並びにROR1陽性の間葉系幹細胞を用いる疾患の予防又は治療方法
Abstract:
(EN) The purpose of the present invention is to provide: new mesenchymal stem cells having excellent therapeutic effect on various diseases, a new pharmaceutical composition containing the mesenchymal stem cells, and a method for preparing the same. The present invention is ROR1-positive mesenchymal stem cells. Preferably, the ROR1-positive mesenchymal stem cells are CD29-, CD73-, CD90-, CD105-, and CD166-positive, and are derived from an umbilical cord or fat.
(FR) L'objet de la présente invention est de pourvoir à : de nouvelles cellules souches mésenchymateuses ayant un excellent effet thérapeutique sur diverses maladies, une nouvelle composition pharmaceutique contenant lesdites cellules souches mésenchymateuses, et leur procédé de préparation. La présente invention porte sur des cellules souches mésenchymateuses positives à ROR1. De préférence, les cellules souches mésenchymateuses positives à ROR1 sont positives à CD29, CD73, CD90, CD105 et CD166, et sont dérivées du cordon ombilical ou du tissu adipeux.
(JA) 本発明は、各種疾患に対して優れた治療効果を奏する新規の間葉系幹細胞及びその間葉系幹細胞を含んだ新規の医薬組成物、並びにそれらの調製方法を提供することを目的とする。 本発明は、ROR1陽性の間葉系幹細胞である。上記ROR1陽性の間葉系幹細胞は、CD29、CD73、CD90、CD105及びCD166陽性であること、臍帯又は脂肪由来であることが好ましい。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)