Search International and National Patent Collections

1. (WO2017037711) ANALOGUES OF VDAC1-DERIVED PEPTIDES

Pub. No.:    WO/2017/037711    International Application No.:    PCT/IL2016/050958
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: C07K 14/435
C07K 14/08
A61K 38/17
A61P 35/00
A61P 1/16
Applicants: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
Inventors: SHOSHAN-BARMATZ, Varda
Title: ANALOGUES OF VDAC1-DERIVED PEPTIDES
Abstract:
The present invention relates to peptides comprising analogues of VDAC1- derived peptides having improved pharmacokinetic characteristics compared to the native parent peptides, which are effective in impairing cell energy production, in inducing apoptosis and cell death, particularly of cancerous cells, in eliminating cancer stem cells and in reducing symptoms associated with fat accumulation in liver cells particularly with nonalcoholic fatty liver disease (NAFLD) and symptoms associated thereto