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1. (WO2017037707) ANTIBODIES SPECIFIC TO HUMAN T-CELL IMMUNOGLOBULIN AND ITIM DOMAIN (TIGIT)

Pub. No.:    WO/2017/037707    International Application No.:    PCT/IL2016/050952
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: C07K 16/28
A61K 39/00
Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
UNIVERSITY OF RIJEKA FACULTY OF MEDICINE
Inventors: MANDELBOIM, Ofer
KAYNAN, Noa S.
TSUKERMAN, Pinchas
JONJIC, Stipan
Title: ANTIBODIES SPECIFIC TO HUMAN T-CELL IMMUNOGLOBULIN AND ITIM DOMAIN (TIGIT)
Abstract:
The present disclosure relates to isolated monoclonal antibodies which bind to the human T-cell immunoglobulin and ITIM domain (TIGIT). The antibodies are characterized by their CDRs sequences. Humanized and bispecific anti TIGIT antibodies are also disclosed. The selected and claimed antibodies show a superior killing activity of effector cells, exhibit high affinity to TIGIT thus prevent the inhibitory effect of the TIGIT receptor and are therefore suitable for use as anti-cancer agents.