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1. (WO2017037695) LATERAL FLOW DIAGNOSTIC DEVICES WITH INTEGRATED ELECTRONIC COMPONENTS AND METHODS OF USE THEREOF

Pub. No.:    WO/2017/037695    International Application No.:    PCT/IL2016/050928
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: G01N 33/543
Applicants: TAMIR, Idan
Inventors: TAMIR, Idan
Title: LATERAL FLOW DIAGNOSTIC DEVICES WITH INTEGRATED ELECTRONIC COMPONENTS AND METHODS OF USE THEREOF
Abstract:
A biological sample device for detecting the presence or absence of specific analytes in a sample is provided. A sample, such as a blood or urine sample or a pre-processed tissue sample is collected on a porous pad. A first membrane in liquid communication with the sample pad includes an analyte-specific, electro actively- labeled detection reagent reactive with the an analyte. A second membrane in liquid communication with the first membrane includes a biosensor whose surface has been modified by an analyte-specific capture reagent. The analyte-binding capture reagent immobilizes the analyte electroactive label complex on the surface of the biosensor, whereby direct interaction of the electroactive label with the surface of the biosensor generates an electric signal used by an electronic processing unit to determine whether the analyte is present in the sample.