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1. (WO2017037685) BIODEGRADABLE IMPLANT
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Pub. No.: WO/2017/037685 International Application No.: PCT/IB2016/055301
Publication Date: 09.03.2017 International Filing Date: 05.09.2016
IPC:
A61L 27/16 (2006.01) ,A61L 27/20 (2006.01) ,A61L 27/52 (2006.01) ,A61L 27/54 (2006.01) ,A61L 27/58 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
16
obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
14
Macromolecular materials
20
Polysaccharides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
52
Hydrogels or hydrocolloids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
54
Biologically active materials, e.g. therapeutic substances
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
58
Materials at least partially resorbable by the body
Applicants:
UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG [ZA/ZA]; 1 Jan Smuts Avenue, Braamfontein 2050 Johannesburg, Gauteng, ZA
Inventors:
PILLAY, Viness; ZA
DU TOIT, Lisa Claire; ZA
CHOONARA, Yahya Essop; ZA
RAMBURRUN, Poornima; ZA
KUMAR, Pradeep; ZA
Agent:
DESSINGTON & ASSOCIATES, INC.; Summit Park, 495 Summit Road, Morningside 2196 Johannesburg, Gauteng, ZA
Priority Data:
2015/0654404.09.2015ZA
Title (EN) BIODEGRADABLE IMPLANT
(FR) IMPLANT BIODÉGRADABLE
Abstract:
(EN) This invention relates to biodegradable implants comprising a hydrogel carrier matrix having dispersed therein a multitude of particles, wherein each of the multitude of particles and/or the hydrogel carrier matrix includes an active pharmaceutical ingredient (API) for the treatment of transected peripheral nerve injuries. Each of the multitude of particles and/or the hydrogel carrier matrix includes pristine polymer particles, preferably the pristine polymer particles may be polymethylmethacrylate polymers and derivatives thereof, preferably poly(methacrylic-co-methyl methacrylate) (PMMA). The spheroidal particles may each be formed from an outer shell including a chitosan (CHT) poly(methacrylic-co-methyl methacrylate) (PMMA) polyelectrolyte complex (CHT-PMMA-PEC) and an inner core including crosslinked chitosan having dispersed therein PMMA nanoparticles.
(FR) La présente invention concerne des implants biodégradables comprenant une matrice de support d'hydrogel dans laquelle est dispersée une multitude de particules, chacune de la multitude de particules et/ou la matrice de support d'hydrogel comprenant un composant pharmaceutique actif (API) pour le traitement de lésions de nerf périphérique sectionné transversalement. Chacune de la multitude de particules et/ou la matrice de support d'hydrogel comprend des particules de polymère vierge, de préférence les particules de polymère vierge peuvent être des polymères de poly(méthacrylate de méthyle) et des dérivés de ceux-ci, de préférence un poly (acide méthacrylique-co-méthacrylate de méthyle) (PMMA). Les particules sphéroïdes peuvent chacune être formées à d'une enveloppe externe comprenant un complexe de chitosane (CHT)-poly(acide méthacrylique-co-méthacrylate de méthyle) (PMMA)-polyélectrolyte (CHT-PMMA-PEC) et un noyau interne comprenant du chitosane réticulé comportant, dispersées dans celui-ci, des nanoparticules de PMMA.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)