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1. (WO2017037682) SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS

Pub. No.:    WO/2017/037682    International Application No.:    PCT/IB2016/055291
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sun Sep 04 01:59:59 CEST 2016
IPC: C07D 405/14
C07D 413/14
C07D 405/12
C07D 417/14
A61K 31/506
A61K 31/4427
A61P 29/00
Applicants: LUPIN LIMITED
Inventors: RAMDAS, Vidya
LORIYA, Rajeshkumar, Maganlal
BANERJEE, Moloy
PATIL, Pradeep, Rangrao
JOSHI, Advait, Arun
DATRANGE, Laxmikant, Shamlal
WALKE, Deepak, Sahebrao
KHAN, Talha, Hussain
DAS, Amit, Kumar
GOTE, Ganesh, Navinchandra
KALHAPURE, Vaibhav, Madhukar
PALLE, Venkata, P.
KAMBOJ, Rajender, Kumar
Title: SULFONAMIDE COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS
Abstract:
The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly NaV1.7. The invention also relates to process for the preparation of the compounds of the invention. (I)