Search International and National Patent Collections

1. (WO2017037662) AN IMPROVED PROCESS FOR THE PREPARATION OF PAROXETINE AND ITS INTERMEDIATE

Pub. No.:    WO/2017/037662    International Application No.:    PCT/IB2016/055261
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: C07D 211/32
C07D 211/76
C07D 405/12
C07B 53/00
Applicants: PIRAMAL ENTERPRISES LIMITED
Inventors: MORTHALA, Raghavendar Rao
ROY, Arnab
MAITY, Tapas
PATLOLLA, Baswaraj
RAJAPPA, Murali
MAJUMDER, Nilanjan
PATEL, Chirag
KRISHNAMURTHY, Dhileepkumar
JANGARI, Santhosh Reddy
JAGTAP, Anant
MANNEM, Phani Kumar
ARWAL, Pulendarreddy
Title: AN IMPROVED PROCESS FOR THE PREPARATION OF PAROXETINE AND ITS INTERMEDIATE
Abstract:
The present invention provides an improved process for the preparation of N-protected ((3S,4R)- 4-(4-fluorophenyl)piperidin-3-yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable salts. The process comprises reaction of compound (II) with amido-malonate compound (C) in the presence of a chiral catalyst and optionally a dehydrating agent to obtain compound (B); followed by reduction of (B) in the presence of a reducing agent to provide compound (A).