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1. (WO2017037634) TGF-Β-RECEPTOR ECTODOMAIN FUSION MOLECULES AND USES THEREOF

Pub. No.:    WO/2017/037634    International Application No.:    PCT/IB2016/055204
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: C07K 19/00
C07K 14/71
C07K 16/00
C07K 16/24
C07K 16/28
C12N 15/62
C12N 5/10
Applicants: NATIONAL RESEARCH COUNCIL OF CANADA
Inventors: ZWAAGSTRA, John C.
SULEA, Traian
JARAMILLO, Maria
O'CONNOR, Maureen D.
LENFERINK, Anne E G
Title: TGF-Β-RECEPTOR ECTODOMAIN FUSION MOLECULES AND USES THEREOF
Abstract:
The present invention relates, in general, to polypeptides capable of binding and neutralizing transforming growth factor beta (TGF-beta) ligands, and uses of these polypeptides for treating disorders related to TGF-beta expression or activation (e.g. cancer and fibrotic diseases), and methods of making such molecules.