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1. (WO2017037596) AMORPHOUS SOLID DISPERSION OF LCZ-696

Pub. No.:    WO/2017/037596    International Application No.:    PCT/IB2016/055106
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: A61K 31/41
C07D 257/04
C07C 233/47
Applicants: DR. REDDY'S LABORATORIES LIMITED
Inventors: CHENNURU, Ramanaiah
PEDDY, Vishweshwar
SUSARLA, Naga Lakshmi Ramana
Title: AMORPHOUS SOLID DISPERSION OF LCZ-696
Abstract:
The present application relates to amorphous solid dispersion of LCZ-696 with one or more pharmaceutically acceptable carrier. Specifically, the present application relates to amorphous solid dispersion of LCZ-696 with one or more pharmaceutically acceptable carrier selected from a group of hydroxypropyl methylcellulose phthalate, povidone, silicon dioxide (syloid) and mixtures thereof. The present application also relates to process for preparation of amorphous solid dispersion of LCZ-696 with one or more pharmaceutically acceptable carrier. Further the present application relates to pharmaceutical composition comprising amorphous solid dispersion of LCZ-696 with one or more pharmaceutically acceptable carrier.