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1. (WO2017037595) NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS
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Pub. No.: WO/2017/037595 International Application No.: PCT/IB2016/055104
Publication Date: 09.03.2017 International Filing Date: 26.08.2016
IPC:
C07C 311/16 (2006.01) ,A61K 31/167 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15
Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
16
having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
167
having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
GLENMARK PHARMACEUTICALS S.A. [CH/CH]; Chemin de la Combeta 5 2300 La Chaux-de-Fonds, CH
Inventors:
DAS, Sanjib; IN
GHARAT, Laxmikant Atmaram; IN
HARDE, Rajendra Laxman; IN
SHELKE, Dnyaneshwar Eknath; IN
PARDESHI, Shailesh Ramesh; IN
THOMAS, Abraham; IN
KHAIRATKAR-JOSHI, Neelima; IN
SHAH, Daisy Manish; IN
BAJPAI, Malini; IN
Priority Data:
3299/MUM/201528.08.2015IN
Title (EN) NOVEL CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS
(FR) NOUVEAUX COMPOSÉS CARBOXYLIQUES UTILISÉS COMME MODULATEURS DE ROR GAMMA
Abstract:
(EN) The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
(FR) La présente invention concerne de nouveaux composés carboxyliques de formule (I) et leurs sels pharmaceutiquement acceptables, où R1, R2, R3, R4, R5, R6, Ra, Rb, n, m et p sont tels que définis ici. Lesdits composés sont actifs en tant que modulateurs du récepteur orphelin apparenté au récepteur des rétinoïdes gamma t (RORγt). Ces composés empêchent, inhibent ou suppriment l'action de RORγt et sont donc utiles pour traiter des maladies, des troubles, des syndromes ou des pathologies médiés par RORγt tels que, par exemple, la douleur, l'inflammation, la broncho-pneumopathie chronique obstructive, l'asthme, la polyarthrite rhumatoïde, la colite, la sclérose en plaques, le psoriasis, les maladies neurodégénératives et le cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)