Search International and National Patent Collections

1. (WO2017037586) COMBINATION THERAPY USING PI3K INHBITOR AND MDM2 INHIBITOR

Pub. No.:    WO/2017/037586    International Application No.:    PCT/IB2016/055075
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: A61K 45/06
A61K 31/4439
A61K 31/496
A61K 31/506
A61K 31/5377
A61P 35/00
Applicants: NOVARTIS AG
CAPONIGRO, Giordano
HORN-SPIROHN, Thomas
LEHAR, Joseph
Inventors: CAPONIGRO, Giordano
HORN-SPIROHN, Thomas
LEHAR, Joseph
Title: COMBINATION THERAPY USING PI3K INHBITOR AND MDM2 INHIBITOR
Abstract:
The present disclosure pertains to a pharmaceutical combination comprising (a) an alpha- isoform specific PI3K inhibitor, (b) an MDM2 inhibitor, and optionally (c) a BCL-2 inhibitor; combined preparations and pharmaceutical compositions thereof; the uses of such combination in the treatment or prevention of cancer; and methods of treating or preventing cancer a subject in need thereof comprising administering a therapeutically effective amount of such combination.