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1. (WO2017037577) NEW USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2017/037577 International Application No.: PCT/IB2016/055045
Publication Date: 09.03.2017 International Filing Date: 24.08.2016
IPC:
A61K 31/225 (2006.01) ,A61K 31/41 (2006.01) ,A61K 31/437 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/12 (2006.01)
[IPC code unknown for A61K 31/225][IPC code unknown for A61K 31/41][IPC code unknown for A61K 31/437][IPC code unknown for A61P 9][IPC code unknown for A61P 9/12]
Applicants:
GODTFREDSEN, Sven Erik [DK/US]; US (US)
ZAPPE, Dion Hubert [US/US]; US (US)
GUO, Weinong [US/US]; US (US)
ZHANG, Jack Ziyu [US/US]; US (US)
NOVARTIS AG [CH/CH]; Lichtstrasse 35 4056 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
Inventors:
GODTFREDSEN, Sven Erik; US
ZAPPE, Dion Hubert; US
GUO, Weinong; US
ZHANG, Jack Ziyu; US
Agent:
LARBIG, Karen; CH
Priority Data:
62/211,07528.08.2015US
Title (EN) NEW USE
(FR) NOUVELLE UTILISATION
Abstract:
(EN) The present invention relates to methods and pharmaceutical compositions for reducing arterial stiffness in a human patient showing at least one symptom selected from increased pulse wave velocity (PWV) and increased pulse pressure (PP) comprising administration to said patient of a therapeutically effective amount or a prophylactically effective amount of a combination of a therapeutic agent blocking the angiotensin receptor and a therapeutic agent inhibiting the NEP enzyme, in particular of a combination of sacubitril or a pharmaceutically acceptable salt thereof and valsartan or a pharmaceutically acceptable salt thereof in a 1:1 molar ratio.
(FR) La présente invention concerne des procédés et des compositions pharmaceutiques permettant de réduire la rigidité artérielle chez un patient humain présentant au moins un symptôme choisi parmi une augmentation de vitesse d'ondes d'impulsion (VOI) et l'augmentation de la pression d'impulsion (PI), comprenant l'administration audit patient d'une quantité efficace au plan thérapeutique ou prophylactique d'une combinaison d'un agent thérapeutique bloquant le récepteur de l'angiotensine et d'un agent thérapeutique inhibant l'enzyme NEP, en particulier d'une combinaison de sacubitril ou d'un sel pharmaceutiquement acceptable de celui-ci et de valsartan ou d'un sel pharmaceutiquement acceptable de celui-ci dans un rapport molaire de 1/1.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)