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1. (WO2017037563) IDENTIFICATION OF PROTEINS IN THE ABSENCE OF PEPTIDE IDENTIFICATIONS

Pub. No.:    WO/2017/037563    International Application No.:    PCT/IB2016/054990
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Aug 20 01:59:59 CEST 2016
IPC: G01N 33/68
G06F 19/10
G06F 19/18
H01J 49/00
Applicants: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventors: SHERMAN, James Andrew
TATE, Stephen A.
Title: IDENTIFICATION OF PROTEINS IN THE ABSENCE OF PEPTIDE IDENTIFICATIONS
Abstract:
A plurality of measured product ion spectra are produced using a DIA tandem mass spectrometry method for a sample of two or more known proteins. A desired confidence probability for the identification of at least one known protein of two or more known proteins is received. Two or more combinations of N theoretical product ions that are exclusive to the at least one known protein are calculated. The at least one known protein is identified by finding product ions in the plurality of measured product ion spectra that match two or more of the two or more combinations of N theoretical product ions that provide a combined confidence probability greater than or equal to the desired confidence probability.