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1. (WO2017037555) METHOD TO IMPROVE MS/MS SPECTRAL QUALITY FROM MRM TRIGGERED IDA

Pub. No.:    WO/2017/037555    International Application No.:    PCT/IB2016/054778
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Wed Aug 10 01:59:59 CEST 2016
IPC: H01J 49/00
G01N 33/68
Applicants: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventors: JARVIS, Michael
LE BLANC, Yves
COX, David Michael
Title: METHOD TO IMPROVE MS/MS SPECTRAL QUALITY FROM MRM TRIGGERED IDA
Abstract:
Systems and methods are provided for enabling or disabling a DMS device during an IDA method. Each cycle of the method includes a survey scan step, producing a precursor ion mass spectrum, and an MS/MS scan step. During the MS/MS scan step, one or more user-defined MS/MS scans are performed that correspond to compounds of interest found in the precursor ion mass spectrum. With each user-defined MS/MS scan, a DMS enable parameter that determines if the DMS device is enabled or disabled and one or more DMS parameters necessary to enable the DMS device for the corresponding compound of interest are received. During the MS/MS scan step, for each user-defined MS/MS scan, the DMS device is enabled or disabled according to the DMS enable parameter and one or more parameters of the DMS device are set according to the one or more DMS parameters.