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1. (WO2017037298) A COMBINATION THERAPY COMPRISING VARLITINIB AND AN ANTICANCER AGENT
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Pub. No.: WO/2017/037298 International Application No.: PCT/EP2016/070888
Publication Date: 09.03.2017 International Filing Date: 05.09.2016
Chapter 2 Demand Filed: 03.07.2017
IPC:
A61K 31/51 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
51
Thiamines, e.g. vitamin B1
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
ASLAN PHARMACEUTICALS PTE LIMITED [SG/SG]; 83 Clemenceau Avenue #12-03 UE Square Singapore, 239920, SG
STERLING IP [GB/GB]; Orion House Bessemer Road Welwyn Garden City Hertfordshire AL7 1HH, GB (TT)
Inventors:
LINDMARK, Bertil; SG
OOI, Lisa; SG
Agent:
STERLING IP; Orion House Bessemer Road Welwyn Garden City Hertfordshire AL7 1HH, GB
HAMBLETON, Bernadette; GB
Priority Data:
1515712.604.09.2015GB
1515714.204.09.2015GB
1515716.704.09.2015GB
1515718.304.09.2015GB
1605583.201.04.2016GB
1608660.517.05.2016GB
62/217,33211.09.2015US
62/217,34611.09.2015US
Title (EN) A COMBINATION THERAPY COMPRISING VARLITINIB AND AN ANTICANCER AGENT
(FR) TRAITEMENT COMBINÉ COMPRENANT DU VARLITINIB ET UN AGENT ANTICANCÉREUX
Abstract:
(EN) In one aspect the present disclosure provides a method of sensitizing a cancer patient to chemotherapy by administering a combination therapy comprising; a) a therapeutically effective amount of a compound of formula (I) an enantiomer thereof or a pharmaceutically acceptable salts of any one of the same, and b) a chemotherapeutic agent or a combination of chemotherapeutic agents.
(FR) Dans un aspect, la présente invention concerne un procédé de sensibilisation d'un patient cancéreux à une chimiothérapie par administration d'un traitement combiné comprenant : a) une quantité thérapeutiquement efficace d'un composé de formule (I), d'un énantiomère de celui-ci ou d'un sel pharmaceutiquement acceptable de l'un quelconque des éléments précédents, et b) un agent chimiothérapeutique ou une combinaison d'agents chimiothérapeutiques
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)