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1. (WO2017037292) COMBINATION OF A DHODH INHIBITOR AND A HER INHIBITOR FOR USE IN THE TREATMENT OF CANCER

Pub. No.:    WO/2017/037292    International Application No.:    PCT/EP2016/070874
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Tue Sep 06 01:59:59 CEST 2016
IPC: A61K 31/51
A61P 35/00
Applicants: ASLAN PHARMACEUTICALS PTE LIMITED
STERLING IP
Inventors: LINDMARK, Bertil
MCHALE, Mark Thomas
OOI, Lisa
Title: COMBINATION OF A DHODH INHIBITOR AND A HER INHIBITOR FOR USE IN THE TREATMENT OF CANCER
Abstract:
The present disclosure provides method of treating a cancer patient comprising administering a therapeutically effect amount of a DHODH inhibitor and a therapeutically effective amount of an inhibitor of a HER receptor, for example an inhibitor of at least HER2. Also provided is a combination therapy comprising a HER inhibitor and a DHODH inhibitor for use in the treatment of cancer and use of a HER inhibitor and a DHODH inhibitor in the manufacture of a combination therapy for the treatment of cancer.