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1. (WO2017037196) STABILIZED VIRAL CLASS I FUSION PROTEINS

Pub. No.:    WO/2017/037196    International Application No.:    PCT/EP2016/070654
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: A61K 39/12
A61K 39/145
A61K 39/21
C07K 2/00
Applicants: JANSSEN VACCINES & PREVENTION B.V.
Inventors: LANGEDIJK, Johannes, Petrus, Maria
Title: STABILIZED VIRAL CLASS I FUSION PROTEINS
Abstract:
The present invention provides stable pre-fusion class I fusion protein in the pre-fusion conformation, comprising one or more mutations in the hinge-loop that is present between the base helix and the RR1.