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1. (WO2017037190) USE OF MICRO-RNAS CIRCULATING IN THE BLOOD SERUM OR BLOOD PLASMA FOR IDENTIFYING PATIENTS REQUIRING A BIOPSY AND AS A MARKER FOR THE DIFFERENTIAL DIAGNOSIS OF INDIVIDUAL NON-ISCHEMIC CARDIOMYOPATHIES OR STORAGE DISEASES AFFECTING THE HEART

Pub. No.:    WO/2017/037190    International Application No.:    PCT/EP2016/070643
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: C12Q 1/68
Applicants: IKDT INSTITUT KARDIALE DIAGNOSTIK UND THERAPIE GMBH
Inventors: SCHULTHEISS, Heinz-Peter
LASSNER, Dirk
ROHDE, Maria
SIEGISMUND, Christine
KOHLENBERG, Max
Title: USE OF MICRO-RNAS CIRCULATING IN THE BLOOD SERUM OR BLOOD PLASMA FOR IDENTIFYING PATIENTS REQUIRING A BIOPSY AND AS A MARKER FOR THE DIFFERENTIAL DIAGNOSIS OF INDIVIDUAL NON-ISCHEMIC CARDIOMYOPATHIES OR STORAGE DISEASES AFFECTING THE HEART
Abstract:
The invention relates to the use of certain micro-RNAs circulating in the blood serum or blood plasma in the form of diagnostic profiles as a marker in an in vitro method for distinguishing between patients for which a myocardial biopsy is necessary for the diagnostic identification of a heart muscle disease and patients for which a myocardial biopsy is not necessary, and for the optional differential diagnosis of individual non-ischemic cardiomyopathies or storage diseases affecting the heart.