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1. (WO2017037180) AUTOMATED ANALYSIS OF CELLULAR SAMPLES HAVING INTERMIXING OF ANALYTICALLY DISTINCT PATTERNS OF ANALYTE STAINING

Pub. No.:    WO/2017/037180    International Application No.:    PCT/EP2016/070621
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: G06K 9/00
Applicants: VENTANA MEDICAL SYSTEMS, INC.
F. HOFFMANN-LA ROCHE AG
Inventors: NGUYEN, Kien
CHEFD'HOTEL, Christophe
Title: AUTOMATED ANALYSIS OF CELLULAR SAMPLES HAVING INTERMIXING OF ANALYTICALLY DISTINCT PATTERNS OF ANALYTE STAINING
Abstract:
Systems and methods discussed herein include, among other things, a method comprising quantifying analyte staining of a biological compartment in a region in which said staining is intermixed with analyte staining of an analytically-distinct distinct biological compartment. Disclosed systems and methods include, for example, a system and method for identifying membrane staining of an analyte of interest in regions where diffuse membrane staining is intermixed with cytoplasmic staining and/or punctate staining is disclosed. Disclosed systems and methods include, for example, a system and method for quantifying membrane staining of an analyte of interest in tissue or cytological samples having regions in which membrane staining is intermixed with cytoplasmic staining and/or punctate staining.