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1. (WO2017037089) METHODS AND COMPOSITIONS USING BIFIDOBACTERIUM LONGUM TO TREAT OR PREVENT DEPRESSIVE SYMPTOMS

Pub. No.:    WO/2017/037089    International Application No.:    PCT/EP2016/070461
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: A61K 35/745
A61P 25/24
Applicants: NESTEC S.A.
Inventors: BERGONZELLI DEGONDA, Gabriela
ALVES NUNES, Tiago
MARQUARDT, Valerie
SCHMITT, Jeroen, Antonius, Johannes
Title: METHODS AND COMPOSITIONS USING BIFIDOBACTERIUM LONGUM TO TREAT OR PREVENT DEPRESSIVE SYMPTOMS
Abstract:
Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to treat or prevent a depressive symptom. Prolonged anti-depressive effects can continue after administration of the compositions is ended. Non-limiting examples of a depressive symptom which can be treated or prevented include depressed mood; sadness; anxiety; "empty" feelings; loss of interest or pleasure; irritability; restlessness; changes in appetite or weight; sleep disturbances; lack of or decreased energy; feelings of worthlessness; guilt; helplessness; anger and hostility; difficulty in thinking, concentrating, or making decisions; hopelessness; tiredness; fatigue; memory difficulties; tearfulness; brooding; phobias; excessive worry over physical health; sexual dysfunction; persistent physical symptoms that do not respond to treatment; and combinations thereof. These depressive symptoms can be associated with a depressive state or depressive disorder or can be found sub-clinically or not associated with these depressive states/disorders (e.g., not part of a syndrome or psychiatric disorder).