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1. (WO2017037081) COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY
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Pub. No.: WO/2017/037081 International Application No.: PCT/EP2016/070453
Publication Date: 09.03.2017 International Filing Date: 31.08.2016
IPC:
C07J 5/00 (2006.01) ,A61K 31/573 (2006.01) ,A61P 5/44 (2006.01) ,A61P 25/16 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
5
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57
substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573
substituted in position 21, e.g. cortisone, dexamethasone, prednisone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
38
of the suprarenal hormones
44
Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
UNIVERSITÀ DEGLI STUDI DI FERRARA [IT/IT]; Via Ludovico Ariosto, 35 44121 Ferrara, IT
Inventors:
PEDRINI, Paola; IT
FERRO, Sergio; IT
Agent:
SPADARO, Marco; IT
LOCAS, Davide; IT
CANTALUPPI, Stefano; IT
FABRIS, Stefano; IT
SUSANETTO, Carlo; IT
MORABITO, Sara; IT
LEONE, Mario; IT
CURRADO, Luisa; IT
Priority Data:
10201500004837303.09.2015IT
Title (EN) COMPOUNDS HAVING ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITY
(FR) COMPOSÉS AYANT UNE ACTIVITÉ ANTI-INFLAMMATOIRE ET ANTIOXYDANTE
Abstract:
(EN) The present invention relates to new compounds of formula (1) wherein R is -C(=O)CH2OH or -CH(OH)CH2OH; R1, is =O or OH; R2 is H or OH; R3 is H or C1-C4alkyl; R4 is H or C1C4alkyl. These compounds are obtained by a process using at least one bacterium belonging to the Actinobacteria class, preferably belonging to the Rhodococcus genus. Thanks to their antiinflammatory and anti-oxidant properties, the compounds of the invention can be advantageously used in the treatment of inflammatory diseases, autoimmune diseases and of diseases in need of a joined anti-inflammatory and anti-oxidant activity.
(FR) La présente invention concerne de nouveaux composés de formule (1) dans laquelle R est -C(=O)CH2OH ou -CH(OH)CH2OH ; R1, est =O ou OH ; R2 est un atome H ou un groupe OH ; R3 est un atome H ou un groupe alkyle en C1 à C4 ; R4 est un atome H ou un groupe alkyle en C1 à C4. Ces composés sont obtenus grâce à un procédé utilisant au moins une bactérie appartenant à la classe des Actinobacteria, appartenant préférablement au genre Rhodococcus. Grâce à leurs propriétés anti-inflammatoires et antioxydantes, les composés de l’invention peuvent être avantageusement utilisés dans le traitement des maladies inflammatoires, des maladies auto-immunes et des maladies ayant besoin d’une activité à la fois anti-inflammatoire et antioxydante.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)