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1. (WO2017037057) NOVEL MIRNA BIOMARKERS AND USE THEREOF
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Pub. No.: WO/2017/037057 International Application No.: PCT/EP2016/070407
Publication Date: 09.03.2017 International Filing Date: 30.08.2016
IPC:
C12N 15/113 (2010.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
HUMMINGBIRD DIAGNOSTICS GMBH [DE/DE]; Im Neuenheimer Feld 583 69120 Heidelberg, DE
Inventors:
BACKES, Christina; DE
KELLER, Andreas; DE
MEESE, Eckart; DE
Agent:
GELING, Andrea; DE
Priority Data:
15183409.002.09.2015EP
Title (EN) NOVEL MIRNA BIOMARKERS AND USE THEREOF
(FR) NOUVEAUX BIOMARQUEURS À BASE DE MIARN ET LEUR UTILISATION
Abstract:
(EN) The present invention relates to novel isolated nucleic acid molecules (novel miRNAs and novel miRNA precursor molecules) as well as vectors, host cells, primers, cDNA-transcripts, polynucleotides derived from said isolated nucleic acid molecules and their use in diagnosis and therapy. Furthermore the present invention relates to methods and kits for diagnosing a disease, such as Multiple Sclerosis (MS) or Alzheimer's Disease (AD) employing said novel isolated nucleic acid molecules (novel miRNAs molecules).
(FR) La présente invention concerne de nouvelles molécules isolées d'acides nucléiques (nouveaux ARNmi et nouvelles molécules précurseurs d'ARNmi), ainsi que des vecteurs, des cellules hôtes, des amorces, des produits de transcription de l'ADNc, des polynucléotides obtenus à partir desdites molécules isolées d'acides nucléiques et leur utilisation à des fins diagnostiques et thérapeutiques. En outre, la présente invention concerne des procédés et des kits permettant de diagnostiquer une maladie, telle que la sclérose en plaques (SEP) ou la maladie d'Alzheimer (MA), mettant en œuvre lesdites nouvelles molécules isolées d'acides nucléiques (nouvelles molécules d'ARNmi).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)