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1. (WO2017037022) COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS

Pub. No.:    WO/2017/037022    International Application No.:    PCT/EP2016/070320
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Tue Aug 30 01:59:59 CEST 2016
IPC: A61K 31/27
A61K 31/42
A61K 31/505
A61P 35/02
Applicants: THE BROAD INSTITUTE, INC.
THE GENERAL HOSPITAL CORPORATION
BAYER PHARMA AKTIENGESELLSCHAFT
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventors: SYKES, David B.
SCADDEN, David
LEWIS, Timothy A.
JANZER, Andreas
MEYER, Hanna
STÖCKIGT, Detlef
Title: COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS
Abstract:
The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as 6-fluoro-2-(2'-fluoro-[1,1'- biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid).