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1. (WO2017036962) SMALL APERTURE LARGE ELECTRODE NANOPORE CELL AND METHOD OF MANUFACTURE
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Pub. No.: WO/2017/036962 International Application No.: PCT/EP2016/070196
Publication Date: 09.03.2017 International Filing Date: 26.08.2016
IPC:
G01N 33/487 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
487
of liquid biological material
Applicants:
GENIA TECHNOLOGIES, INC. [US/US]; 2841 Scott Boulevard Santa Clara, CA 95050, US (US)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel, CH (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Strasse 116 68305 Mannheim, DE (DE)
Inventors:
FOSTER, John; US
MAGER, Morgan; US
Agent:
HILDEBRANDT, Martin; DE
BURGER, Alexander; DE
EISENMANN, Ulrike; DE
GOEHRING, Frank; DE
JENNI, Wolfgang; DE
MERTES, Maria; DE
MISERA, Simon; DE
NASER, Werner; DE
SKOLAUT, Alexander; DE
WOLTERS, Brit; DE
HEINEMEYER, Thomas; DE
Priority Data:
14/841,12731.08.2015US
Title (EN) SMALL APERTURE LARGE ELECTRODE NANOPORE CELL AND METHOD OF MANUFACTURE
(FR) CELLULE DE NANOPORE À PETITE OUVERTURE ET GRANDE ÉLECTRODE, ET PROCÉDÉ DE FABRICATION
Abstract:
(EN) A nanopore cell includes a conductive layer and a working electrode disposed above the conductive layer and at the bottom of a well into which an electrolyte may be contained, such that at least a portion of a top base surface area of the working electrode is exposed to the electrolyte. The nanopore cell further includes a first insulating wall disposed above the working electrode and surrounding a lower section of a well, and a second insulating wall disposed above the first insulating wall and surrounding an upper section of the well, forming an overhang above the lower section of the well. The upper section of the well includes an opening that a membrane may span across, and wherein a base surface area of the opening is smaller than the at least a portion of the top base surface area of the working electrode that is exposed to the electrolyte.
(FR) Selon l'invention, une cellule de nanopore comprend une couche conductrice et une électrode de travail disposée au-dessus de la couche conductrice et au fond d'un puits dans lequel un électrolyte peut être présent, de sorte qu'au moins une partie d'une zone de surface de base supérieure de l'électrode de travail soit exposée à l'électrolyte. Le cellule de nanopore comprend en outre: une première paroi isolante disposée au-dessus de l'électrode de travail et entourant une section inférieure d'un puits; et une seconde paroi isolante disposée au-dessus de la première paroi isolante et entourant une section supérieure du puits, en formant un porte-à-faux au-dessus de la section inférieure du puits. La section supérieure du puits présente une ouverture pouvant être recouverte d'une membrane, une zone de surface de base de l'ouverture étant plus petite que ladite au moins une partie de la zone de surface de base supérieure de l'électrode de travail exposée à l'électrolyte.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)