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1. (WO2017036884) A LESINURAD, FREE FORM / LESINURAD ETHYL ESTER CO-CRYSTAL

Pub. No.:    WO/2017/036884    International Application No.:    PCT/EP2016/069998
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Aug 25 01:59:59 CEST 2016
IPC: C07D 249/12
Applicants: SANDOZ AG
Inventors: STEFINOVIC, Marijan
REECE, Hayley
Title: A LESINURAD, FREE FORM / LESINURAD ETHYL ESTER CO-CRYSTAL
Abstract:
The present disclosure relates to a co-crystal comprising 2-[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylsulfanyl]acetic acid (lesinurad, free form) and ethyl-2-[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylsulfanyl]acetate (lesinurad ethyl ester). The present disclosure also generally relates to the use of a lesinurad, free form / lesinurad ethyl ester co-crystal for the preparation of amorphous lesinurad.