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1. (WO2017036811) MICRORNAS FOR THE TREATMENT OF HEART DISEASES

Pub. No.:    WO/2017/036811    International Application No.:    PCT/EP2016/069636
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Aug 19 01:59:59 CEST 2016
IPC: C12N 15/113
A61K 31/713
A61P 9/10
Applicants: UNIVERSITEIT MAASTRICHT
ACADEMISCH ZIEKENHUIS MAASTRICHT
Inventors: WINDT, DE, Leon Johannes
DIRKX, Ellen
GIACCA, Mauro
Title: MICRORNAS FOR THE TREATMENT OF HEART DISEASES
Abstract:
The invention relates to the field of molecular biology and medicine, more specifically the invention is directed towards the treatment, delay and amelioration of heart diseases. More in particular, microRNAs are provided that induce cardiac regeneration by inducing cell cycle proliferation of cardiomyocytes, thereby treating or ameliorating heart diseases associated with a loss of cardiomyocytes or cardiomyocyte function. Such diseases include myocardial infarction, cardiomyopathy of ischemic or non-ischemic origin, myocarditis and heart failure. More in particular, the invention relates to a composition comprising a microRNA selected from the group consisting of microRNA 106b, microRNA 93 or microRNA 25 and the complements thereof, for use in the treatment, prevention, delay or amelioration of a heart disease.