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1. (WO2017036805) A SEPARATION MATRIX AND A METHOD OF SEPARATING ANTIBODIES

Pub. No.:    WO/2017/036805    International Application No.:    PCT/EP2016/069557
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Aug 19 01:59:59 CEST 2016
IPC: B01J 20/24
B01D 15/38
B01J 20/286
B01J 20/32
C07K 1/22
B01J 20/28
Applicants: GE HEALTHCARE BIOPROCESS R&D AB
Inventors: LACKI, Karol, Maciej
BLOM, Hans
SKOGLAR, Helena
LAURIN, Linus
Title: A SEPARATION MATRIX AND A METHOD OF SEPARATING ANTIBODIES
Abstract:
The invention discloses a separation matrix comprised of porous spherical particles to which antibody-binding protein ligands have been covalently immobilized, wherein the density of said ligands is in the range of 10.5 - 15 mg/ml and the volume-weighted median diameter of said particles is in the range of 30 - 55 µm. The invention further discloses a method of separation of antibodies by affinity chromatography which employs the said separation matrix within a chromatography column.