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1. (WO2017036597) METHOD OF MAKING A CROSS-LINKED POLYMER GEL AND DEVICE FOR PERFORMING THE METHOD

Pub. No.:    WO/2017/036597    International Application No.:    PCT/EP2016/001470
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Sep 01 01:59:59 CEST 2016
IPC: C08J 3/075
A61L 27/52
A61K 8/73
A61K 47/36
B01F 7/00
B01D 61/24
B01D 61/28
B01D 63/00
A61K 31/728
C08B 37/08
C08J 3/24
Applicants: MERZ PHARMA GMBH & CO. KGAA
Inventors: FRIEDRICH, Josef
Title: METHOD OF MAKING A CROSS-LINKED POLYMER GEL AND DEVICE FOR PERFORMING THE METHOD
Abstract:
The present invention relates to a method of making a composition, the composition comprising a cross-linked polymer and water, comprising at least the following steps: a) providing a first mixture, comprising at least one polymer and an aqueous alkaline solution; b) generating a gel by cross-linking the at least one polymer with a cross- linking agent; c) neutralizing the generated gel by using a neutralization solution; d) optionally adding a second mixture, comprising a cross-linked and/or non-cross- linked polymer and water, to the neutralized gel obtained in step c); e) dialyzing the gel obtained in step d) or dialyzing the gel obtained in step c) and optionally subsequent addition of the second mixture, comprising a cross-linked and/or non-cross-linked polymer and water; and f) filling the dialyzed gel obtained in step e) into a container, wherein at least two or three or four or five or all of steps a) to f) are automated.