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1. (WO2017036577) METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF

Pub. No.:    WO/2017/036577    International Application No.:    PCT/EP2016/001376
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Aug 11 01:59:59 CEST 2016
IPC: C07D 217/14
C07B 53/00
Applicants: MERCK PATENT GMBH
Inventors: EBERHARDT, Luc
WAECHTLER, Andreas
MAILLARD, David
LEHMANN, Stefan
Title: METHOD FOR THE PRODUCTION OF PRAZIQUANTEL AND PRECURSORS THEREOF
Abstract:
The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound (I) and subsequent cyclization.