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1. (WO2017036545) METHOD FOR DETERMINING CARBOHYDRATES STRUCTURE

Pub. No.:    WO/2017/036545    International Application No.:    PCT/EP2015/070195
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 04 01:59:59 CEST 2015
IPC: G01N 33/68
Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
FREIE UNIVERSITÄT BERLIN
Inventors: HOFMANN, Johanna
HAHM, Heung Sik
SEEBERGER, Peter
PAGEL, Kevin
Title: METHOD FOR DETERMINING CARBOHYDRATES STRUCTURE
Abstract:
The present invention relates to a method for determining in an expedient manner and with minimal sample consumption the structure of an unknown carbohydrate by using ion mobility-mass spectrometry (IM-MS) in negative ionization mode and fragmentation and a database containing structures of carbohydrates and/or of the fragments of the negative ions of carbohydrates, andfor each of the structures of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the negative ion thereof, and for each of the structures of the fragments of the negative ions of the target carbohydrates the collision cross section value and the mass-to-charge ratio value of the fragment of the negative ion of the target carbohydrate.