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1. (WO2017036408) S-(-)-1-PROPYL-2',6'-AMINOXYLENEFORMYLPIPERIDINE CRYSTAL AND SUSTAINED RELEASE PREPARATION THEREOF

Pub. No.:    WO/2017/036408    International Application No.:    PCT/CN2016/097784
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Sep 02 01:59:59 CEST 2016
IPC: C07D 211/60
A61K 9/10
A61K 9/19
A61K 9/22
A61P 23/02
Applicants: SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
四川海思科制药有限公司
Inventors: YE, Qiang
叶强
YAN, Pangke
严庞科
FENG, Wei
冯卫
WAN, Hua
万华
ZHANG, Xuanmiao
张轩邈
WANG, Donghai
汪东海
Title: S-(-)-1-PROPYL-2',6'-AMINOXYLENEFORMYLPIPERIDINE CRYSTAL AND SUSTAINED RELEASE PREPARATION THEREOF
Abstract:
Provided are a long-effective amide local anesthetic: S-(-)-1-propyl-2',6'-aminoxyleneformylpiperidine crystal, a sustained release preparation thereof, and their preparation method. Compared with an existing hydrochloride preparation, the preparation made from the crystal has a particularly good property of continuously and slowly releasing drug and maintaining an effective blood drug concentration, and shows an excellent long-term local analgesic effect.