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1. (WO2017036389) COMPOSITION OF CANAGLIFLOZIN AND PHARMACEUTICAL EXCIPIENT, AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2017/036389    International Application No.:    PCT/CN2016/097411
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Wed Aug 31 01:59:59 CEST 2016
IPC: A61K 31/381
A61P 3/10
Applicants: CHANGZHOU FANGNAN PHARMACEUTICALS, LTD.
常州方楠医药技术有限公司
Inventors: ZHANG, Xini
张席妮
XIONG, Zhigang
熊志刚
HU, Tao
胡涛
ZI, Chunpeng
资春鹏
Title: COMPOSITION OF CANAGLIFLOZIN AND PHARMACEUTICAL EXCIPIENT, AND PREPARATION METHOD THEREFOR
Abstract:
A composition of Canagliflozin and a pharmaceutical excipient, and a preparation method therefor. In the composition, Canagliflozin is amorphous. The present invention further relates to a pharmaceutical composition containing a Canagliflozin solid dispersion, comprising a solid dispersion formed by Canagliflozin and an organic carrier, and at least one pharmaceutically acceptable excipient, wherein Canagliflozin is amorphous. The pharmaceutical composition of the present invention increases the dissolution rate of Canagliflozin, and helps improve the bioavailability of medicine.