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1. (WO2017036357) CATHEPSIN K INHIBITOR AND APPLICATION THEREOF
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Pub. No.: WO/2017/036357 International Application No.: PCT/CN2016/096882
Publication Date: 09.03.2017 International Filing Date: 26.08.2016
IPC:
C07C 255/29 (2006.01) ,C07C 255/46 (2006.01) ,C07C 209/42 (2006.01) ,C07C 215/48 (2006.01) ,C07C 233/54 (2006.01) ,C07C 277/02 (2006.01) ,A61K 31/275 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
255
Carboxylic acid nitriles
01
having cyano groups bound to acyclic carbon atoms
24
containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
29
containing cyano groups and acylated amino groups bound to the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
255
Carboxylic acid nitriles
45
having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
46
to carbon atoms of non-condensed rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
209
Preparation of compounds containing amino groups bound to a carbon skeleton
30
by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
42
by reduction of nitrogen-to-nitrogen bonds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
46
having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
48
with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
53
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
54
having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
277
Preparation of guanidine or its derivatives, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
02
of guanidine from cyanamide, calcium cyanamide or dicyandiamides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
275
Nitriles; Isonitriles
Applicants:
广东东阳光药业有限公司 SUNSHINE LAKE PHARMA CO., LTD. [CN/CN]; 中国广东省东莞市 松山湖科技产业园区 Northern Industrial Area, Songshan Lake Dongguan, Guangdong 523000, CN
Inventors:
王晓军 WANG, Xiaojun; CN
周平健 ZHOU, Pingjian; CN
阳传文 YANG, Chuanwen; CN
黄常伟 HUANG, Changwei; CN
熊绍辉 XIONG, Shaohui; CN
张英俊 ZHANG, Yingjun; CN
张健存 ZHANG, Jiancun; CN
Priority Data:
201510548889129.08.2015CN
Title (EN) CATHEPSIN K INHIBITOR AND APPLICATION THEREOF
(FR) INHIBITEUR DE CATHEPSINE K ET SON APPLICATION
(ZH) 组织蛋白酶K抑制剂及其用途
Abstract:
(EN) Provided are a cathepsin K inhibitor and application thereof, and specifically is a compound having a structure represented by formula (I) and being used to treat or prevent a cathepsin dependent disease. In particular, the cathepsin is a cathepsin K, and the compound and a pharmaceutical composition thereof can function as a bone resorption inhibitor to treat associated diseases.
(FR) La présente invention concerne un inhibiteur de cathepsine K et son application, et concerne spécifiquement un composé ayant une structure représentée par la formule (I) et étant utilisé pour traiter ou prévenir une maladie dépendante de la cathepsine. En particulier, la cathepsine est une cathepsine K, et le composé et une composition pharmaceutique de celui-ci peuvent fonctionner comme un inhibiteur de résorption osseuse pour traiter des maladies associées.
(ZH) 一种组织蛋白酶K的抑制剂及其用途,具体为一类具有如式(I)所示的结构,用于治疗或预防组织蛋白酶依赖性病症的化合物,特别地,所述的组织蛋白酶为组织蛋白酶K,所述化合物及其药物组合物可以用作骨吸收抑制剂来治疗相关疾病。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)