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1. (WO2017036302) APPLICATION OF GENETIC ENGINEERING BACTERIUM OF ATTENUATED SALMONELLA TYPHIMURIUM IN PREPARATION OF MEDICINE FOR TREATING LIVER CANCER

Pub. No.:    WO/2017/036302    International Application No.:    PCT/CN2016/095629
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Thu Aug 18 01:59:59 CEST 2016
IPC: C12N 1/21
C12N 15/74
A61K 48/00
A61P 35/00
A61P 1/16
C12R 1/42
Applicants: NANJING SINOGEN BIOTECH & PHARMACEUTICAL INC.
南京华贞生物医药科技有限公司
Inventors: ZHAO, Allanzijian
赵子建
ZHOU, Sujin
周素瑾
LIN, Yan
林艳
ZHAO, Zhenggang
赵正刚
LI, Fanghong
李芳红
Title: APPLICATION OF GENETIC ENGINEERING BACTERIUM OF ATTENUATED SALMONELLA TYPHIMURIUM IN PREPARATION OF MEDICINE FOR TREATING LIVER CANCER
Abstract:
Provided is an application of a genetic engineering bacterium of attenuated Salmonella typhimurium in preparation of medicine for treating liver cancer. The bacterium is attenuated Salmonella typhimurium VNP20009 carrying a plasmid cloned with a methionine synthase gene. Also provided is a construction method for the bacterium.