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1. (WO2017036136) A-GROUP AND C-GROUP NEISSERIA MENINGITIDIS POLYSACCHARIDE CONJUGATE VACCINE ACTIVATING PROCESS

Pub. No.:    WO/2017/036136    International Application No.:    PCT/CN2016/078081
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Fri Apr 01 01:59:59 CEST 2016
IPC: A61K 39/095
A61K 39/385
A61P 31/04
C08B 37/00
Applicants: CHENGDU OLYMVAX BIOPHARMACEUTICAL CO.,LTD
成都欧林生物科技股份有限公司
Inventors: WU, Qiang
吴强
WU, Changhua
伍长华
TAN, Yong
谭勇
Title: A-GROUP AND C-GROUP NEISSERIA MENINGITIDIS POLYSACCHARIDE CONJUGATE VACCINE ACTIVATING PROCESS
Abstract:
Disclosed is an A-group and C-group Neisseria meningitidis polysaccharide conjugate vaccine activating process, comprising the following steps: (1) cultivating Neisseria meningitidis; (2) extracting crude polysaccharide by using the cultivated Neisseria meningitidis; (3) purifying the crude polysaccharide to prepare refined Neisseria meningitidis polysaccharide; and (4) activating the refined polysaccharide by using CDAP, and then reacting with ADH to generate a polysaccharide derivative.