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1. (WO2017036128) ALKALOID COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTIVIRAL AGENT AGAINST HERPES SIMPLEX VIRUS TYPE 1

Pub. No.:    WO/2017/036128    International Application No.:    PCT/CN2016/077649
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Wed Mar 30 01:59:59 CEST 2016
IPC: C07D 405/06
C07D 215/22
C12P 17/12
C12P 17/16
A61P 31/22
C12R 1/645
Applicants: THE OCEAN UNIVERSITY OF CHINA
中国海洋大学
Inventors: SHAO, Changlun
邵长伦
WANG, Changyun
王长云
MU, Xiaofeng
牟晓凤
XU, Rufang
胥汝芳
Title: ALKALOID COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTIVIRAL AGENT AGAINST HERPES SIMPLEX VIRUS TYPE 1
Abstract:
An alkaloid compound, preparation method thereof and use thereof as an antiviral agent against herpes simplex virus type 1 (HSV-1). The preparation comprises: first performing strain fermentation and culturing of a fungus, Scopulariopsis sp. (TA01-33); and extracting and concentrating the fermentation liquid, then sequentially performing normal phase chromatography with silica gel, column chromatography with Sephadex LH-20 gel and high-performance liquid chromatography (HPLC), so as to obtain a compound of formula I, and performing a series of routine chemical reactions on the compound of formula I to obtain compounds of formulas II-V. The present invention further provides an antiviral agent against HSV-1, wherein the compounds of formulas I-V in the present invention or pharmaceutically acceptable salts thereof are used to treat a disease caused by HSV-1.