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1. (WO2017035767) METHOD AND SYSTEM FOR GENETIC MANIPULATION OF SOUND-SENSITIVE ION CHANNELS

Pub. No.:    WO/2017/035767    International Application No.:    PCT/CN2015/088706
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Wed Sep 02 01:59:59 CEST 2015
IPC: A61N 7/00
Applicants: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
中国科学院深圳先进技术研究院
Inventors: ZHENG, Hairong
郑海荣
NIU, Lili
牛丽丽
LIU, Xin
刘新
MENG, Long
孟龙
QIU, Weibao
邱维宝
QIAN, Ming
钱明
CAI, Feiyan
蔡飞燕
XIAO, Yang
肖杨
WANG, Congzhi
王丛知
Title: METHOD AND SYSTEM FOR GENETIC MANIPULATION OF SOUND-SENSITIVE ION CHANNELS
Abstract:
A method and system for genetic manipulation of sound-sensitive ion channels. The method comprises: acquiring a sound wave (101); focusing the sound wave on endogenous mechanosensitive ion channels of nerve cells to be stimulated, opening the endogenous mechanosensitive ion channels, and/or focusing the sound wave on exogenous mechanosensitive ion channels of the nerve cells to be stimulated, and opening the exogenous mechanosensitive ion channels, to change a membrane potential of the nerve cells (102). This solution implements noninvasive, accurate, and selectively-specific nerve operation and regulation by means of a sound wave.