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1. (WO2017035664) ENHANCED THERMAL STABILITY FOR ADENOVIRAL VECTORS THROUGH SPRAY DRYING

Pub. No.:    WO/2017/035664    International Application No.:    PCT/CA2016/051046
Publication Date: Fri Mar 10 00:59:59 CET 2017 International Filing Date: Sat Sep 03 01:59:59 CEST 2016
IPC: C12N 7/00
C12N 1/04
C12N 15/861
C12N 15/87
Applicants: MCMASTER UNIVERSITY
Inventors: THOMPSON, Michael
XING, Zhou
LECLAIR, Daniel Adam
CRANSTON, Emily
Title: ENHANCED THERMAL STABILITY FOR ADENOVIRAL VECTORS THROUGH SPRAY DRYING
Abstract:
The present application includes stabilized adenovirus compositions comprising an adenovirus and an excipient, wherein the excipient comprises a mixture of dextran and mannitol in amounts effective to maintain at least 40% of the adenovirus activity after spray drying.