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1. (WO2017035528) TRIAZOLOPYRIDINES AND TRIAZOLOPYRIMIDINES THAT LOWER STRESS-INDUCED P-TAU

Pub. No.:    WO/2017/035528    International Application No.:    PCT/US2016/049270
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Tue Aug 30 01:59:59 CEST 2016
IPC: C07D 487/04
A61K 31/519
A61K 45/06
Applicants: NANTNEURO, LLC
Inventors: JOHN, Varghese
BUZKO, Oleksandr
BREDESEN, Dale
SPILMAN, Patricia
JAGODZINSKA, Barbara
Title: TRIAZOLOPYRIDINES AND TRIAZOLOPYRIMIDINES THAT LOWER STRESS-INDUCED P-TAU
Abstract:
Pharmaceutical compounds, compositions, methods, and uses therefor are presented using selected triazolopyridines and triazolopyrimidines to inhibit or reduce phosphorylation of tau proteins or that act as antagonists of corticotropin-releasing factor. Viewed from another perspective, compounds, compositions, and methods are presented for treating or preventing symptoms of Alzheimer's disease by inhibiting or reducing the phosphorylation of tau proteins.