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1. (WO2017035508) COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN
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Pub. No.: WO/2017/035508 International Application No.: PCT/US2016/049106
Publication Date: 02.03.2017 International Filing Date: 26.08.2016
IPC:
C07K 14/32 (2006.01) ,C07K 14/33 (2006.01) ,C12N 15/62 (2006.01) ,C12N 15/63 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
32
from Bacillus (G)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
33
from Clostridium (G)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy Street Cambridge, Massachusetts 02138, US
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, Massachusetts 02138, US
IPSEN PHARMA S.A.S. [FR/FR]; 65, quai Georges Gorse F-92100 Boulogne-Billancourt, FR
Inventors:
COLLIER, R. John; US
CHIU, Isaac; US
PENTELUTE, Bradley L.; US
FOSTER, Keith Alan; GB
PALAN, Shilpa; GB
LIU, Sai Man; GB
Agent:
JARRELL, Brenda Herschbach; US
EISENSTEIN, Ronald I.; US
FITZGERALD, Mark J.; US
BENN, Susanna C.; US
KARTTUNEN CONTARINO, Leena H.; US
CROSBY, David F.; US
HUFF, Shayne Y.; US
MILLS, Tari W.; US
PTASHKA, Teresa A.; US
SUMMERFORD, Candace M.; US
KLING, Nicole D.; US
Priority Data:
62/210,61027.08.2015US
Title (EN) COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN
(FR) COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE LA DOULEUR
Abstract:
(EN) Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.
(FR) La présente invention concerne des protéines de fusion issues du génie protéique qui se lient et qui ciblent des neurones nocicepteurs, des compositions comprenant ces protéines de fusion issues du génie protéique, et des procédés de traitement de la douleur utilisant ces protéines de fusion issues du génie protéique ou des compositions contenant les protéines de fusion issues du génie protéique. Les protéines de fusion issues du génie protéique contiennent des domaines dérivés de toxines protéiques telles que la toxine de l’anthrax, la famille des toxines de Clostridium botulinum, les toxines contenant du disulfure, et les toxines du type constituant AB.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)