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1. (WO2017035484) PERFUSION MANIFOLD ASSEMBLY

Pub. No.:    WO/2017/035484    International Application No.:    PCT/US2016/049033
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: C12M 1/34
B01L 3/00
C12M 1/00
C12M 3/00
G01N 33/00
G01N 33/50
Applicants: EMULATE, INC.
Inventors: LEVNER, Daniel
SLIZ, Josiah, Daniel
HINOJOSA, Christopher David
THOMPSON II, Guy Robert
MARTINUS VAN RUIJVEN, Petrus
SOLOMON, Matthew Daniel
POTZNER, Christian, Alexander
TUOHY, Patrick, Sean
WEN, Norman
GOMES, Joshua
FREAKE, Jacob
SABIN, Doug
Title: PERFUSION MANIFOLD ASSEMBLY
Abstract:
Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly. A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.