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1. (WO2017035454) SCAVENGING DISSOLVED OXYGEN VIA ACOUSTIC DROPLET VAPORIZATION
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Pub. No.: WO/2017/035454 International Application No.: PCT/US2016/048934
Publication Date: 02.03.2017 International Filing Date: 26.08.2016
IPC:
A61K 31/02 (2006.01) ,A61K 9/00 (2006.01) ,A61K 9/10 (2006.01) ,A61K 9/107 (2006.01) ,A61K 31/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
02
Halogenated hydrocarbons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
Applicants:
UNIVERSITY OF CINCINNATI [US/US]; 51 Goodman Drive Suite 240 Cincinnati, Ohio 45221, US
Inventors:
RADHAKRISHNAN, Kirthi; US
HOLLAND, Christy K.; US
HAWORTH, Kevin J.; US
Agent:
SCHABOWSKY, Richard-Henry; US
LORENTZ, Joshua A.; US
EVERETT, Denise M.; US
LIVINGSTON, Jennifer L.; US
OBERHAUS, Geoffrey L.; US
TENT, Brian A.; US
NEAL, Cynthia A.; US
RERICHA, Nicholaus R.; US
Priority Data:
62/210,05626.08.2015US
Title (EN) SCAVENGING DISSOLVED OXYGEN VIA ACOUSTIC DROPLET VAPORIZATION
(FR) PIÉGEAGE DE L'OXYGÈNE DISSOUS VIA UNE VAPORISATION ACOUSTIQUE DE GOUTTELETTES
Abstract:
(EN) Methods and compositions for treating a patient for a condition characterized by an excess blood concentration of dissolved gas in at least one targeted region of the patient are provided. The method comprises administering a composition comprising a perfluorocarbon droplet emulsion into the blood of the patient; insonifying the at least one target region sufficient to achieve formation of microbubbles by droplet vaporization of at least a portion of the perfluorocarbon droplets present in the blood; whereby a concentration gradient favoring movement of gas molecules from the blood into the microbubbles is established for a time frame.
(FR) L'invention concerne des procédés et des compositions pour traiter un patient atteint d'un trouble caractérisé par une concentration sanguine en gaz dissous en excès dans au moins une zone ciblée du patient. Le procédé consiste à administrer une composition comprenant une émulsion de gouttelettes de perfluorocarbone dans le sang du patient ; à insonifier ladite au moins une région cible de manière suffisante pour obtenir la formation de microbulles par vaporisation de gouttelettes d'au moins une partie des gouttelettes de perfluorocarbone présentes dans le sang ; un gradient de concentration favorisant le déplacement des molécules de gaz du sang dans les microbulles étant établi pendant un intervalle de temps.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)