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1. (WO2017035453) COMPOSITIONS AND METHODS FOR TREATING SOLID TUMORS

Pub. No.:    WO/2017/035453    International Application No.:    PCT/US2016/048933
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: A61K 31/167
A61K 31/706
C07H 19/06
A61K 38/17
A61P 35/00
Applicants: THE JOHNS HOPKINS UNIVERSITY
Inventors: ZAHNOW, Cynthia
BAYLIN, Stephen B.
TOPPER, Michael
STONE, Meredith
Title: COMPOSITIONS AND METHODS FOR TREATING SOLID TUMORS
Abstract:
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating solid tumors. In a specific embodiment, a method for treating a solid tumor in a patient having cancer comprises the step of administering to the patient a demethylating agent, a histone deacetylase (HDAC) inhibitor and a checkpoint inhibitor.