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1. (WO2017035438) COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES
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Pub. No.: WO/2017/035438 International Application No.: PCT/US2016/048890
Publication Date: 02.03.2017 International Filing Date: 26.08.2016
IPC:
A61K 31/395 (2006.01)
[IPC code unknown for A61K 31/395]
Applicants:
THE TEXAS A&M UNIVERSITY SYSTEM [US/US]; 3369 TAMU College Station, TX 77843-3369, US
Inventors:
REDDY, Manchi CM; US
SACCHETTINI, James C.; US
VALLURU, Spandana; US
Agent:
LECOINTE, Michelle; US
Priority Data:
62/210,22426.08.2015US
Title (EN) COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES
(FR) COMPOSITIONS ET PROCÉDÉS POUR LA SENSIBILISATION DE PARASITES À UN MÉDICAMENT
Abstract:
(EN) Compositions and methods for inhibiting and/or sensitizing or re-sensitizing a parasite to an antiparasitic drug are provided. The compositions can comprise a an arylphenoxypropionate derivative, an aryloxyphenoxyacetate derivative, an aryloxyphenylacetate derivative, one or more substituted quinols, or a pharmaceutically acceptable salt, hydrate, or prodrug thereof, or a combination thereof in an amount and formulation sufficient to sensitize the parasite to the drug, treating infection of a patient by a parasite with a drug, or to prevent symptomatic infection of a patient by a parasite with a drug.
(FR) L'invention concerne des compositions et des procédés pour inhiber et/ou sensibiliser, ou sensibiliser à nouveau, un parasite à un médicament antiparasitaire. Les compositions peuvent comprendre un dérivé d'arylphénoxypropionate, un dérivé d'aryloxyphénoxyacétate, un dérivé d'aryloxyphénylacétate, au moins un quinol substitué, ou un sel, hydrate ou promédicament de ceux-ci, pharmaceutiquement acceptable, ou une combinaison de ceux-ci, dans une quantité et formulation suffisantes pour sensibiliser le parasite au médicament, traiter l'infection parasitaire d'un patient avec un médicament, ou prévenir une infection symptomatique parasitaire d'un patient avec un médicament.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)