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1. (WO2017035419) COMPOSITES FOR SEPARATING RARE CELLS

Pub. No.:    WO/2017/035419    International Application No.:    PCT/US2016/048801
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Sat Aug 27 01:59:59 CEST 2016
IPC: G01N 33/543
G01N 33/569
G01N 33/574
G01N 33/532
Applicants: NVIGEN, INC.
Inventors: FU, Aihua
ZHOU, Hua
Title: COMPOSITES FOR SEPARATING RARE CELLS
Abstract:
The present invention generally relates to composites for capturing rare cells in samples, the preparation and the use thereof. The composite comprises a bead operably linked to polyethylene glycol (PEG) compound; an analyte-capturing member operably linked to the bead, said analyte-capturing member specifically binding to a surface marker of the rare cells, wherein the composite has a diameter ranging from about 100 to about 3000 nm. The composite may capture rare cells with high cell capture yield, low non-specific capture, high cell viability and low clump formation.