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1. (WO2017035411) ETHER COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS

Pub. No.:    WO/2017/035411    International Application No.:    PCT/US2016/048793
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: A01N 43/00
Applicants: ACHILLION PHARMACEUTICALS, INC.
Inventors: WILES, Jason Allan
PHADKE, Avinash S.
DESHPANDE, Milind
AGARWAL, Atul
CHEN, Dawei
GADHACHANDA, Venkat Rao
HASHIMOTO, Akihiro
PAIS, Godwin
WANG, Qiuping
WANG, Xiangzhu
GREENLEE, William
Title: ETHER COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS
Abstract:
Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and I‴ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.