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1. (WO2017035375) METHODS FOR STEM CELL TRANSPLANTATION

Pub. No.:    WO/2017/035375    International Application No.:    PCT/US2016/048738
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: A61K 35/14
A61K 35/17
A61K 35/28
A61P 37/06
C12N 5/02
Applicants: THE UAB RESEARCH FOUNDATION
Inventors: LAMB, Lawrence S.
MINEISHI, Shin
SAAD, Ayman
Title: METHODS FOR STEM CELL TRANSPLANTATION
Abstract:
The present disclosure provides methods of hematopoietic stem cell transplantation (HSCT). In particular, the present disclosure provides a method of HSCT using a combination of an in-vivo T-cell depletion method, with an ex-vivo method of γδ T cell expansion and αβ T cell depletion. The in-vivo T-cell depletion method depletes (in-vivo) the alloreactive T cells that would otherwise increase the risk of GvHD.