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1. (WO2017035359) MODIFIED ANTHRAX TOXIN PROTECTIVE ANTIGEN

Pub. No.:    WO/2017/035359    International Application No.:    PCT/US2016/048706
Publication Date: Fri Mar 03 00:59:59 CET 2017 International Filing Date: Fri Aug 26 01:59:59 CEST 2016
IPC: C07K 14/325
A61K 39/07
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors: LIU, Shi-Hui
LEPPLA, Stephen H.
BUGGE, Thomas H.
WEIN, Alexander N.
PETERS, Diane E.
LIU, Jie
CHEN, Kuang-Hua
Title: MODIFIED ANTHRAX TOXIN PROTECTIVE ANTIGEN
Abstract:
Disclosed is a Bacillus anthracis protective antigen (PA) comprising a PA amino acid sequence, wherein one or more of amino acid residues I207, I210, E654, I656, R659, M662, Y681, and L687, as defined by reference to SEQ ID NO: 1, are, independently, substituted, with the proviso that amino acid residue I207 is not substituted with alanine and amino acid residue I210 is not substituted with alanine. Related compositions, nucleic acids, recombinant expression vectors, host cells, populations of cells, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.